Department of Chemistry

Selected research products

Senatore R, Malik M, Spreitzer M, Holzer W, Pace V. (2020) Direct and Chemoselective Electrophilic Monofluoromethylation of Heteroatoms (O-, S-, N-, P-, Se-) with Fluoroiodomethane. Organic letters 22(4) 1345-1349 [DOI  PMID]

Miele M, D'Orsi R, Sridharan V, Holzer W, Pace V. (2019) Highly chemoselective difluoromethylative homologation of iso(thio)cyanates: expeditious access to unprecedented alpha,alpha-difluoro(thio)amides. Chemical communications (Cambridge, England) 55(86) 12960-12963 [DOI  PMID]

Miele M, Citarella A, Micale N, Holzer W, Pace V. (2019) Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent. Organic letters 21(20) 8261-8265 [DOI  PMID]

Vittorio S, Seidel T, Germano MP, Gitto R, Ielo L, Garon A, Rapisarda A, Pace V, Langer T, De Luca L. (2019) A Combination of Pharmacophore and Docking-based Virtual Screening to Discover new Tyrosinase Inhibitors. Molecular informatics [DOI  PMID]

Karuppasamy M, Vachan BS, Vinoth P, Muthukrishnan I, Nagarajan S, Ielo L, Pace V, Banik S, Maheswari CU, Sridharan V. (2019) Direct Access to 9-Chloro-1H-benzo[b]furo[3,4-e]azepin-1-ones via Palladium(II)-Catalyzed Intramolecular syn-Oxypalladation/Olefin Insertion/sp(2)-C-H Bond Activation Cascade. Organic letters 21(15) 5784-5788 [DOI  PMID]

Vinoth P, Karuppasamy M, Vachan BS, Muthukrishnan I, Maheswari CU, Nagarajan S, Pace V, Roller A, Bhuvanesh N, Sridharan V. (2019) Palladium-Catalyzed Regioselective Syn-Chloropalladation-Olefin Insertion-Oxidative Chlorination Cascade: Synthesis of Dichlorinated Tetrahydroquinolines. Organic letters 21(9) 3465-3469 [DOI  PMID]

Pace V, Holzer W, Ielo L, Shi S, Meng G, Hanna M, Szostak R, Szostak M. (2019) (17)O NMR and (15)N NMR chemical shifts of sterically-hindered amides: ground-state destabilization in amide electrophilicity. Chemical communications (Cambridge, England) 55(30) 4423-4426 [DOI  PMID]

Monticelli S, Holzer W, Langer T, Roller A, Olofsson B, Pace V. (2019) Sustainable Asymmetric Organolithium Chemistry: Enantio- and Chemoselective Acylations through Recycling of Solvent, Sparteine, and Weinreb "Amine". ChemSusChem 12(6) 1147-1154 [DOI  PMID]

Monticelli S, Colella M, Pillari V, Tota A, Langer T, Holzer W, Degennaro L, Luisi R, Pace V. (2019) Modular and Chemoselective Strategy for the Direct Access to alpha-Fluoroepoxides and Aziridines via the Addition of Fluoroiodomethyllithium to Carbonyl-Like Compounds. Organic letters 21(2) 584-588 [DOI  PMID]

Ielo L, Touqeer S, Roller A, Langer T, Holzer W, Pace V. (2019) Telescoped, Divergent, Chemoselective C1 and C1-C1 Homologation of Imine Surrogates: Access to Quaternary Chloro- and Halomethyl-Trifluoromethyl Aziridines. Angewandte Chemie (International ed. in English) 58(8) 2479-2484 [DOI  PMID]

de la Vega-Hernandez K, Senatore R, Miele M, Urban E, Holzer W, Pace V. (2019) Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent. Organic & biomolecular chemistry 17(7) 1970-1978 [DOI  PMID]

Stadler M, Monticelli S, Seidel T, Luger D, Salzer I, Boehm S, Holzer W, Schwarzer C, Urban E, Khom S, Langer T, Pace V, Hering S. (2019) Design, Synthesis, and Pharmacological Evaluation of Novel beta2/3 Subunit-Selective gamma-Aminobutyric Acid Type A (GABAA) Receptor Modulators. Journal of medicinal chemistry 62(1) 317-341 [DOI  PMID]

Azzena U, Carraro M, Pisano L, Monticelli S, Bartolotta R, Pace V. (2019) Cyclopentyl Methyl Ether: An Elective Ecofriendly Ethereal Solvent in Classical and Modern Organic Chemistry. ChemSusChem 12(1) 40-70 [DOI  PMID]

Rui M, Rossino G, Coniglio S, Monteleone S, Scuteri A, Malacrida A, Rossi D, Catenacci L, Sorrenti M, Paolillo M, Curti D, Venturini L, Schepmann D, Wunsch B, Liedl KR, Cavaletti G, Pace V, Urban E, Collina S. (2018) Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents. European journal of medicinal chemistry 158 353-370 [DOI  PMID]

Castoldi L, Pace V. (2018) Easy as one, two, three. Nature chemistry 10(11) 1081-1082 [DOI  PMID]

Touqeer S, Castoldi L, Langer T, Holzer W, Pace V. (2018) Homologation of halostannanes with carbenoids: a convenient and straightforward one-step access to alpha-functionalized organotin reagents. Chemical communications (Cambridge, England) 54(72) 10112-10115 [DOI  PMID]

Monticelli S, Rui M, Castoldi L, Missere G, Pace V. (2018) A practical guide for using lithium halocarbenoids in homologation reactions. Monatshefte fur chemie 149(7) 1285-1291 [DOI  PMID]

Eller GA, Vilkauskaite G, Sackus A, Martynaitis V, Mamuye AD, Pace V, Holzer W. (2018) An unusual thionyl chloride-promoted C-C bond formation to obtain 4,4'-bipyrazolones. Beilstein journal of organic chemistry 14 1287-1292 [DOI  PMID]

Castoldi L, Monticelli S, Senatore R, Ielo L, Pace V. (2018) Homologation chemistry with nucleophilic alpha-substituted organometallic reagents: chemocontrol, new concepts and (solved) challenges. Chemical communications (Cambridge, England) 54(50) 6692-6704 [DOI  PMID]

Senatore R, Castoldi L, Ielo L, Holzer W, Pace V. (2018) Expeditious and Chemoselective Synthesis of alpha-Aryl and alpha-Alkyl Selenomethylketones via Homologation Chemistry. Organic letters 20(9) 2685-2688 [DOI  PMID]

Castoldi L, Ielo L, Holzer W, Giester G, Roller A, Pace V. (2018) alpha-Arylamino Diazoketones: Diazomethane-Loading Controlled Synthesis, Spectroscopic Investigations, and Structural X-ray Analysis. The Journal of organic chemistry 83(8) 4336-4347 [DOI  PMID]

Parisi G, Colella M, Monticelli S, Romanazzi G, Holzer W, Langer T, Degennaro L, Pace V, Luisi R. (2017) Exploiting a "Beast" in Carbenoid Chemistry: Development of a Straightforward Direct Nucleophilic Fluoromethylation Strategy. Journal of the American Chemical Society 139(39) 13648-13651 [DOI  PMID]

Castoldi L, Holzer W, Langer T, Pace V. (2017) Evidence and isolation of tetrahedral intermediates formed upon the addition of lithium carbenoids to Weinreb amides and N-acylpyrroles. Chemical communications (Cambridge, England) 53(68) 9498-9501 [DOI  PMID]

Pace V, Castoldi L, Mazzeo E, Rui M, Langer T, Holzer W. (2017) Efficient Access to All-Carbon Quaternary and Tertiary alpha-Functionalized Homoallyl-type Aldehydes from Ketones. Angewandte Chemie (International ed. in English) 56(41) 12677-12682 [DOI  PMID]

Parisi G, Degennaro L, Carlucci C, de Candia M, Mastrorilli P, Roller A, Holzer W, Altomare CD, Pace V, Luisi R. (2017) A greener and efficient access to substituted four- and six-membered sulfur-bearing heterocycles. Organic & biomolecular chemistry 15(23) 5000-5015 [DOI  PMID]

Jansa J, Schmidt R, Mamuye AD, Castoldi L, Roller A, Pace V, Holzer W. (2017) Synthesis of tetrasubstituted pyrazoles containing pyridinyl substituents. Beilstein journal of organic chemistry 13 895-902 [DOI  PMID]

Pace V, Holzer W, Meng G, Shi S, Lalancette R, Szostak R, Szostak M. (2017) Corrigendum: Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization. Chemistry (Weinheim an der Bergstrasse, Germany) 23(14) 3496 [DOI  PMID]

Monticelli S, Castoldi L, Murgia I, Senatore R, Mazzeo E, Wackerlig J, Urban E, Langer T, Pace V. (2017) Recent advancements on the use of 2-methyltetrahydrofuran in organometallic chemistry. Monatshefte fur chemie 148(1) 37-48 [DOI  PMID]

Monticelli S, Parisi G, Rui M, de la Vega-Hernandez K, Murgia I, Senatore R, Holzer W, Urban E, Langer T, Pace V. (2016) The Use of the Comins-Meyers Amide in Synthetic Chemistry: an Overview. Natural product communications 11(11) 1729-1732 [PMID]

Rui M, Rossi D, Marra A, Paolillo M, Schinelli S, Curti D, Tesei A, Cortesi M, Zamagni A, Laurini E, Pricl S, Schepmann D, Wunsch B, Urban E, Pace V, Collina S. (2016) Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents. European journal of medicinal chemistry 124 649-665 [DOI  PMID]

Muthukrishnan I, Karuppasamy M, Nagarajan S, Maheswari CU, Pace V, Menendez JC, Sridharan V. (2016) Synthesis of 6,12-Epiminodibenzo[b,f][1,5]diazocines via an Ytterbium Triflate-Catalyzed, AB2 Three-Component Reaction. The Journal of organic chemistry 81(20) 9687-9694 [DOI  PMID]

Rui M, Marra A, Pace V, Juza M, Rossi D, Collina S. (2016) Novel Enantiopure Sigma Receptor Modulators: Quick (Semi-)Preparative Chiral Resolution via HPLC and Absolute Configuration Assignment. Molecules (Basel, Switzerland) 21(9) [DOI  PMID]

Pace V, Holzer W, Meng G, Shi S, Lalancette R, Szostak R, Szostak M. (2016) Structures of Highly Twisted Amides Relevant to Amide N-C Cross-Coupling: Evidence for Ground-State Amide Destabilization. Chemistry (Weinheim an der Bergstrasse, Germany) 22(41) 14494-8 [DOI  PMID]

Pace V, Monticelli S, de la Vega-Hernandez K, Castoldi L. (2016) Isocyanates and isothiocyanates as versatile platforms for accessing (thio)amide-type compounds. Organic & biomolecular chemistry 14(33) 7848-54 [DOI  PMID]

Pace V, Holzer W, De Kimpe N. (2016) Lithium Halomethylcarbenoids: Preparation and Use in the Homologation of Carbon Electrophiles. Chemical record (New York, N.Y.) 16(4) 2061-76 [DOI  PMID]

Vinoth P, Nagarajan S, Maheswari CU, Sudalai A, Pace V, Sridharan V. (2016) Palladium-Catalyzed Internal Nucleophile-Assisted Hydration-Olefin Insertion Cascade: Diastereoselective Synthesis of 2,3-Dihydro-1H-inden-1-ones. Organic letters 18(14) 3442-5 [DOI  PMID]

Pace V, Murgia I, Westermayer S, Langer T, Holzer W. (2016) Highly efficient synthesis of functionalized alpha-oxyketones via Weinreb amides homologation with alpha-oxygenated organolithiums. Chemical communications (Cambridge, England) 52(48) 7584-7 [DOI  PMID]

Pace V, de la Vega-Hernandez K, Urban E, Langer T. (2016) Chemoselective Schwartz Reagent Mediated Reduction of Isocyanates to Formamides. Organic letters 18(11) 2750-3 [DOI  PMID]

Pace V, Pelosi A, Antermite D, Rosati O, Curini M, Holzer W. (2016) Bromomethyllithium-mediated chemoselective homologation of disulfides to dithioacetals. Chemical communications (Cambridge, England) 52(12) 2639-42 [DOI  PMID]

Pace V, Castoldi L, Monticelli S, Safranek S, Roller A, Langer T, Holzer W. (2015) A Robust, Eco-Friendly Access to Secondary Thioamides through the Addition of Organolithium Reagents to Isothiocyanates in Cyclopentyl Methyl Ether (CPME). Chemistry (Weinheim an der Bergstrasse, Germany) 21(52) 18966-70 [DOI  PMID]

Mamuye AD, Castoldi L, Azzena U, Holzer W, Pace V. (2015) Chemoselective efficient synthesis of functionalized beta-oxonitriles through cyanomethylation of Weinreb amides. Organic & biomolecular chemistry 13(7) 1969-73 [DOI  PMID]

Alcantara AR, Pace V, Hoyos P, Sandoval M, Holzer W, Hernaiz MJ. (2014) Chemoenzymatic synthesis of carbohydrates as antidiabetic and anticancer drugs. Current topics in medicinal chemistry 14(23) 2694-711 [DOI  PMID]

Pace V, Rae JP, Procter DJ. (2014) Cu(I)-NHC catalyzed asymmetric silyl transfer to unsaturated lactams and amides. Organic letters 16(2) 476-9 [DOI  PMID]

Pace V, Castoldi L, Holzer W. (2013) Addition of lithium carbenoids to isocyanates: a direct access to synthetically useful N-substituted 2-haloacetamides. Chemical communications (Cambridge, England) 49(75) 8383-5 [DOI  PMID]

Pace V, Castoldi L, Holzer W. (2013) Synthesis of alpha,beta-unsaturated alpha'-haloketones through the chemoselective addition of halomethyllithiums to Weinreb amides. The Journal of organic chemistry 78(15) 7764-70 [DOI  PMID]

Pace V, Rae JP, Harb HY, Procter DJ. (2013) NHC-Cu(I) catalysed asymmetric conjugate silyl transfer to unsaturated lactones: application in kinetic resolution. Chemical communications (Cambridge, England) 49(45) 5150-2 [DOI  PMID]

Pace V, Hoyos P, Alcantara AR, Holzer W. (2013) Chemoselective CaO-mediated acylation of alcohols and amines in 2-methyltetrahydrofuran. ChemSusChem 6(5) 905-10 [DOI  PMID]

Pace V, Vilkauskaite G, Sackus A, Holzer W. (2013) Highly efficient and chemoselective alpha-iodination of acrylate esters through Morita-Baylis-Hillman-type chemistry. Organic & biomolecular chemistry 11(7) 1085-8 [DOI  PMID]

Pace V, Castoldi L, Pregnolato M. (2013) alpha-Amino-alpha'-halomethylketones: synthetic methodologies and pharmaceutical applications as serine and cysteine protease inhibitors. Mini reviews in medicinal chemistry 13(7) 988-96 [DOI  PMID]

Pace V, Hoyos P, Castoldi L, Dominguez de Maria P, Alcantara AR. (2012) 2-Methyltetrahydrofuran (2-MeTHF): a biomass-derived solvent with broad application in organic chemistry. ChemSusChem 5(8) 1369-79 [DOI  PMID]

Pace V, Verniest G, Sinisterra JV, Alcantara AR, De Kimpe N. (2010) Improved Arndt-Eistert synthesis of alpha-diazoketones requiring minimal diazomethane in the presence of calcium oxide as acid scavenger. The Journal of organic chemistry 75(16) 5760-3 [DOI  PMID]

Pace V, Martinez F, Fernandez M, Sinisterra JV, Alcantara AR. (2007) Effective monoallylation of anilines catalyzed by supported KF. Organic letters 9(14) 2661-4 [DOI  PMID]

Courses

• CHIMICA ORGANICA I (CHI0206)
  Corso di laurea in Chimica per la manifattura sostenibile
• CHIMICA ORGANICA I - Corso A (cognomi A-K) (MFN1164)
  Corso di laurea in Chimica e Tecnologie Chimiche
• Carbanion Chemistry in Organic Synthesis (2324)
  PhD in Chemical and Materials Sciences
• Chimica Organica con elementi di biochimica Corso B (SVB0011)
  Scienze Naturali, Scienze dei Sistemi Naturali,
  Evoluzione del comportamento animale e dell’uomo
• NUOVI ORIENTAMENTI IN SINTESI ORGANICA (CHI0057)
  Corso di laurea magistrale in Chimica

Research groups

• SMCO - Sintesi
• SMCO - Sintesi e meccanismi

Activities in agenda

See my calendar

Academic bodies

• Commissione Ricerca
• Consiglio di Dipartimento
• Giunta

Office hours

Previa richiesta via e-mail in accordo con le esigenze del docente e dello studente.